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MOTS-c activates AMPK to improve metabolic function, fat oxidation, and mitochondrial biogenesis

This means the B12 component in a compounded semaglutide formulation is most likely to help patients who are deficient or at risk of deficiency, those eating very little, those following plant-based diets, older adults whose B12 absorption decreases with age, or those with conditions affecting B12 absorption like gastric bypass or certain GI conditions

Your provider can help determine the appropriate schedule based on your goals and response

Can You Get Vitamin B12 Injections If You Are Not Deficient

This is because the risk of toxicity and serious adverse effects from an overdose is rare