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This reaction is common and usually occurs at the beginning of treatment rather than later on

Dihexa is a small peptide derived from angiotensin IV, and it works by activating the hepatocyte growth factor (HGF) pathway and its receptor c-Met, a mechanism that plays a critical role in the process of building new synapses

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doi:10.1002/cjoc.201300061 ZhouW, Shultz JW, Murphy N, Hawkins EM, Bernad L, Good T, Moothart L, Frackman S, Klaubert DH, Bulleit RF, Wood KV (2006) Electrophilic aromatic substituted luciferins as bioluminescent probes for glutathione S-transferase assays