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Sweat makes it worse
Documented protocols describe starting at 20 mcg for the first 2-3 days to assess tolerance, then increasing to 50 mcg if well-tolerated
Moreover, PD patients with elevated SNpc iron content exhibit a 3540% reduction in dopamine transporter specific binding ratio in the sensorimotor putamen, the earliest and most severely affected striatal subregion, indicating striatal dysfunction (24)
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