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324,343 In pancreatic and colorectal cancers, intratumoral -proteobacteria express a long isoform of cytidine deaminase (CDD-L) that catalyzes the deamination of gemcitabine into its inactive metabolite 2,2-difluorodeoxyuridine (dFdU), thereby conferring chemoresistance
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Such a reduction might be critical, as oxidative stress is considered a significant factor in cellular aging
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