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Popoviciu M-S, Pduraru L, Yahya G et al (2023) Emerging role of GLP-1 agonists in obesity: a comprehensive review of randomised controlled trials

Cell Metabolism 2022: 10.1016/j.cmet.2022.07.013 cAMP functional potency, low-receptor-density assays (GIP EC50 0.0643 nM, GLP-1 0.775 nM, glucagon 5.79 nM

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While developed primarily as a weight management tool, the compound appears to affect brain function in ways that extend well beyond appetite suppression

Researchers presenting at ENDO 2026 found that adults with obesity who started a GLP-1 medication became less physically active after beginning treatment