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A study found that TAMs release IL-8, which activates EGFR signaling mediated by Src/STAT3/ERK1/2 in breast cancer cells and contributes to lapatinib resistance in HER2-positive breast cancer cells [193]
The causal relationship was evaluated by multiplicative random effects inverse variance weighted (IVW) method, and further verified by another three MR methods including MR Egger, weighted median, and weighted mode, as well as extensive sensitivity analyses
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Programs are thoughtfully structured to include regular medical check-ins, lifestyle coaching, and flexible support modalitieswhether in-person or via telehealth
Dong JY, Xun P, He K, Qin LQ
