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For example, the Vd of diazepam, lorazepam, and nitrazepam decreased by 3.2-, 1.7-, and 2.1-fold, respectively, in non-obese participants, and their CL and t 1/2 were altered, indicating the need for dose adjustment

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CJC-1295 with DAC (drug affinity complex) exploits this gap by binding to endogenous GHRH receptors and producing sustained GH pulses