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One of the drugs in the combination known as fen-phen a combination of fenfluramine and phentermine was withdrawn in 1997 for damaging heart valves

This would enable us to explore and understand these mechanisms at a deeper level

Referral to endocrinology is appropriate for complex cases, inadequate response, or significant adverse effects

Phentermine may have a role in specific scenariossuch as short-term use (typically 12 weeks or less) in patients with no cardiac historybut evidence increasingly favors GLP-1 monotherapy as a first-line approach due to better safety margins and sustained weight loss