A forward genetic screen for Arabidopsis mutants with up-regulated GSTF8 promoter activity was conducted by fusing a GSTF8 promoter fragment to the luciferase reporter gene
Similarly, authors [3] of the first double-blind, randomized, placebo-controlled clinical trial of oral glutathione (GSH) supplementation performed in healthy adult humans concluded that despite the biochemical plausibility, optimal dose, recommended timing of administration and appropriate choice of outcome measures, no significant changes were observed in oxidative stress biomarkers or erythrocyte glutathione (GSH) concentrations following 4 weeks of oral (2 x 500mg daily) glutathione (GSH) supplementation
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Redox-based regulation of signal transduction: principles, pitfalls, and promises
Jesus Palma AC, Antunes Junior CR, Barreto ESR, et al