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Cycle Guidelines Common Cagrilintide Research Cycle Lengths Approach Short cycle Duration 16 weeks Review Point Week 16 Notes Reaches maintenance just as titration completes Approach Standard cycle Duration 26-32 weeks Review Point Week 26 / 32 Notes Matches Phase 2 trial durations Approach Long cycle Duration 68 weeks Review Point Week 68 Notes Matches REDEFINE 1 and REDEFINE 2 endpoints Cycle length is a research planning choice, not a treatment recommendation

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However, as time progressed to day 7, a slightly higher level of GSH was observed in group 3 (17.570.46 M/g tissue) than in group 1 (15.690.47 M/g tissue) and group 2 (14.740.46 M/g tissue)

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