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Beyond their effects in the GI tract, GLP-1 medications also powerfully affect appetite signaling in the brain
Their evidence base is public: the STEP program studied semaglutide for weight management ( The New England Journal of Medicine , 2021), SURMOUNT studied tirzepatide for weight management (NEJM, 2022), and SURMOUNT-OSA examined tirzepatide in obstructive sleep apnea (NEJM, 2024)
(This is based on when you started the medication not your current weight) BMI of 35 or higher when you started, OR BMI of 30 or higher AND a serious heart or kidney condition, OR BMI of 27 or higher AND a history of heart attack, stroke, or pre-diabetes 3
Mounjaro costs The company that makes Mounjaro, Eli Lilly, says the list price is about $1,070 for a one-month supply