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Long-term ablation of DMH GLP-1R resulted in hyperphagia and obesity, and blunted exendin-4-induced anorexigenic metabolic effects [68,73]

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Further cyclization and chlorination of Compound 6 yielded Compound 7 , which, through a palladium-catalyzed cross-coupling reaction, produced the target molecule, Compound 1 (Scheme 1) (Li et al., 2016)

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Because of the potential side effects and serious concern for certain populations, though, this step is a requirement before considering L-carnitine injectionsespecially since it can interact with certain medications