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The peptide is chemically modified with an N-terminal tyrosine residue to enhance stability and contains a disulfide bond between cysteine residues

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PubMed 22962027 TB-4 Phase 1 human safety first-in-human randomized, double-blind, single- and multiple-dose Phase 1 of recombinant human thymosin 4 in healthy volunteers, no serious adverse events: PubMed 34346165