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By stimulating glucose-dependent insulin secretion and suppressing glucagon production, they are a cornerstone of the treatment of type 2 diabetes (DM2), particularly in patients with a higher risk of cardiovascular disease ( This narrative review describes the complex interplay between GLP-1 signalling and intestinal inflammation, highlighting both the potential benefits and limitations of GLP1 RAs in IBD management, with a particular focus on their promising role in selected obese IBD patients

Proteomics 8 , 28092831 (2008)

It works by mimicking a hormone that stimulates insulin production after meals and reduces appetite

Lilly has six more late-stage studies in the TRIUMPH program underway for retatrutide which are expected to readout by the end of 2026