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Reported preclinical rodent studies have employed diet-induced-obese and GLP-1R knockout mouse models together with indirect calorimetry and pair-feeding designs as experimental tools to examine how the three receptor pathways contribute to measured signaling readouts, and cell and tissue systems have been used to probe hepatic lipid handling at the biochemical level

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J Pharmacol Exp Ther 306:347354

Individual reactions vary, and factors like dosage and diet can influence tolerability