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Liver Function Tests: Semaglutide generally has neutral or beneficial effects on liver enzymes, particularly in patients with metabolic dysfunction-associated steatotic liver disease who may show improvements due to weight loss

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On the other hand, preclinical studies in rodents have shown that co-administration of a long-acting GIPRA synergistically enhances the glucose-lowering and weight-reducing effects of GLP-1RA (44, 75)

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