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Endocrinology 136(8):35853596 Lau J et al (2015) Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide
doi: 10.1210/endocr/bqab079 91 ZhuXLinCLiLHuSCaiXJiL
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A subsequent 2014 paper by Chang and colleagues in Molecules showed that BPC-157, applied at 0.10.5 g/mL in vitro, dose- and time-dependently upregulated growth hormone receptor expression at both mRNA and protein levels in cultured rat Achilles tendon fibroblasts a mechanistic in vitro finding for which numeric fold-changes and p-values are not reported in the abstract
Because GlyNAC supplies the exact rate-limiting amino acid precursors required for glutathione synthesis, it allows each individual cell to upregulate its own production of this master antioxidant based on its specific, localized metabolic needs
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