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Human safety is not established because large human trials have not been completed
Preclinical research models have explored its interactions with angiogenic signaling, tissue response pathways, and receptor-associated biological mechanisms in small-animal and in-vitro studies
On the topical side, the most well-known study used a nano-lipid carrier to help GHK-Cu sink deeper into the skin
Thus, it is likely that GCLC expression is regulated both directly via MYC and indirectly via a MYCregulated miRNA, miR18a, in a contextspecific manner as shown in this study
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