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First, absolute incidence: in the pooled STEP 1 to 3 obesity trials of semaglutide 2.4 mg (the Wegovy weight-management dose), constipation affected 24.2% of patients versus 11.1% on placebo , alongside nausea (43.9%), diarrhoea (29.7%), and vomiting (24.5%)
Celebrities, influencers, and large numbers of people online and on social media singing the praises of GLP-1 RAs coupled with easy online access to drugs have created the perfect storm
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Harness J, Heerden J, Lennquist S, Rothmund M, Barraclough BH, Goode AW, Rosen IB, et al
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