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Transdermal-delivery research has repeatedly demonstrated that microneedle-created channels can increase the skin permeation of hydrophilic and larger molecules by many-fold compared with application to intact skin the exact magnitude depends on needle length, density, molecule size, and how soon after treatment the active is applied
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A rare cause is transcobalamin II deficiency, a genetic condition where your body can't transport B12 (also known as cobalamin) in your body
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