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Progressive tapering of conventional medications as peptide effects develop represents a logical clinical strategy, ideally under medical supervision

During prolonged caloric restriction

Immune function depends on multiple nutrients, highlighting the importance of a varied, nutrient-dense diet even during caloric restriction

In particular, LEAP2 (liver-expressed antimicrobial peptide 2), an endogenous antagonist of the ghrelin receptor GHSR, has emerged as a potential target for mitigating the weight regain often observed after discontinuation of GLP-1-based therapies [22,23]

Researchers explain that weight loss in people who experience GI issues is slightly greater than in those who do not experience this side effect