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: Oral administration PARP: Poly Adp-ribose polymerase PDX: Patient-derived xenograft PFKFB3: 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 PGE2: Prostaglandin E2 ROS: Reactive oxygen species SIRT1: Sirtuin 1 SLC7A11: Solute carrier family 7 member 11 Smad: Drosophila mothers against decapentaplegic protein SPR: Surface plasmon resonance STAT3: Signal transducer and activator of transcription 3 TAMs: Tumor-associated macrophages TFEB: Transcription factor Eb TILs: Tumor-infiltrating lymphocytes TME: Tumor microenvironment TNF-: Tumor necrosis factor TRIM25: Tripartite motif containing 25 VEGF: Vascular endothelial growth factor VEGFR2: Vascular endothelial growth factor receptor 2 References Zhao YP, et al
The down-regulation of the p53 gene protects hair cells from Bcl2 family translocation, cytochrome c translocation, caspase3 activation, and ultimately cell death, as it operates upstream of the mitochondrial apoptotic pathway
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