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Administration of a melanocortin agonist to mice lacking MC4R but not MC3R improves hyperinsulinemia and homeostasis model assessment of insulin resistance (HOMA-IR) scores (Kumar et al., 2009)
Funding This review received no specific funding from public, commercial, or not-for-profit entities
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The mechanisms of protein-triggered GLP-1 secretion are less clear, but the amino acid proportion and composition appear important to the stimulatory effect
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