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The development of active targeting systems (e.g., antibody or peptide-guided) may help address this issue but faces new challenges such as high cost and poor stability

Endocrinology and Metabolism, 289 (6), E1015E1022

Furthermore, studies using a peripherally administered exenatide analogue conjugated to vitamin B12, which is sterically hindered from accessing regions protected by the blood brain barrier, improves glucose control in comparable fashion to unmodified exenatide, presumably at the level of the -cell, but does not induce emesis in the house musk shrew ( Suncus murinus) or rats (78, 79)

Repeat the process with the other nostril

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