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A: The most direct and potent method is Intravenous (IV) administration, as it achieves 100% bioavailability
However, three major reviews didnt show sufficient evidence to support this claim (14, 15, 16)
Withdrawal of COX-2 selective inhibitors rofecoxib and valdecoxib: impact on NSAID and gastroprotective drug prescribing and utilization
Reactive oxygen species, ionizing radiation, and certain chemicals can cause single- and double-strand breaks in DNA 3,4
Selenium level in the serum of patients with OA is significantly lower than that of normal controls (119)
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