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L., Fletcher, R
in: PubMed | Google Scholar | 1 Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada
Your provider should reassess your B12 levels periodically typically every 3 to 6 months to determine whether continued injections are warranted or whether oral supplementation is sufficient to maintain adequate levels
Immortal time bias in pharmaco-epidemiology
The permanent schedule-change protocol If you need to move your injection day permanently (Friday to Thursday, for example), the safe protocol depends on which direction you're moving: Moving to an earlier day in the week (Friday to Thursday): Option 1: Gradual transition Week 1: Take your Friday dose as scheduled Week 2: Take your dose on Thursday (one day early, within safe window) Week 3 onward: Continue Thursday schedule Option 2: Gap transition (more conservative) Week 1: Take your Friday dose as scheduled Week 2: Skip the dose entirely Week 3: Begin Thursday schedule This creates an 8-day gap once, avoiding any dose stacking Moving to a later day in the week (Friday to Saturday): Week 1: Take your Friday dose as scheduled Week 2: Take your dose on Saturday (one day late, safe) Week 3 onward: Continue Saturday schedule Moving to a later day is simpler because you're creating a gap, not compressing doses
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