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Psychiatry 16, 252264

Recent Developments In February 2026 , Pfizer announced positive Phase 2b trial results for its ultra-long-acting injectable GLP-1 (PF-08653944), demonstrating significant weight loss with monthly dosing

One thing that often catches people off guard is the digestive side effects: bloating that seems to come out of nowhere, constipation that lingers, sulfur burps, and stomach discomfort that can make meals feel like a chore

These medications are also approved for pediatric patients aged 12 and older who have obesity

Staying on a tolerable dose long-term beats struggling on the maximum dose and eventually quitting