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The expression of IDO1, TDO2, and other enzymes in the kynurenine pathway varies widely among different tumor types and even among patients with the same type of cancer ( While preclinical studies have demonstrated the potential of targeting the KP to overcome drug resistance, translating these findings into clinical practice will require carefully designed trials

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This combination is commonly referenced in laboratory and preclinical research examining peptidereceptor interactions and biological signalling pathways in controlled research environments

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