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CLA safety caveats Certain CLA isomers, particularly the trans 10 cis 12 isomer, have been associated in some studies with worsened insulin sensitivity

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Clinical studies show that TUDCA, much like UDCA, can improve bile flow and bring down liver enzymes: A multicenter randomized trial found that people with PBC who took 750mg/day of TUDCA for 24 weeks had lower alkaline phosphatase and other liver enzyme levels.4 Unlike UDCA, it did not worsen itching