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A recent regulatory example, accepted by the US EPA, of a non-animal risk assessment for the fungicide chlorothalonil in an occupational scenario combined in vitro PoDs from MucilAir readouts (i.e., TEER, lactate dehydrogenase leakage and resazurin metabolism analyses) with dosimetry information obtained from a computational fluid-particle dynamics (CFPD) model (Corley et al., 2021

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This includes those with kidney disease, thyroid disorders, seizure conditions, or significant cardiovascular history

The activation of the inflammasome complex entails two consecutive signals, namely (122, 123, 125, 126) and (122, 123, 125, 126)