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The absence of cold sensitivity does not mean the medication is ineffective
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Dose escalation occurs gradually within the once-weekly framework: starting at 2.5 mg, then progressing to 5 mg, 10 mg, and up to 15 mg at weekly intervals spaced four weeks apart
While MT2 upregulates the melanogenesis pathway, melanosome transfer from melanocytes to keratinocytes requires UV-induced oxidative stress signaling
The prepared solution is kept in a refrigerator, usually between two and eight degrees Celsius
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