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Ondrejickova O, Ziegelhoeffer A, Gabauer I, Sotnikova R, Styk J, Gibala P, et al
It is possible that a portion of the increase in blood nitrate/nitrite could have been due to an increase in physical activity of certain subjects assigned to ALCA, as an increase in resting nitrate/nitrite has been reported previously for individuals involved in exercise training [5456]
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The mechanism underlying carnitine's anti-aging effects involves multiple pathways: restoration of mitochondrial cardiolipin content and membrane integrity, enhancement of fatty acid oxidation to reduce lipotoxic stress, reduction of protein oxidation and carbonyl formation, improvement of calcium homeostasis and cellular signaling, and activation of stress resistance pathways that promote cellular resilience
