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The needles physically breached the stratum corneum and delivered berberine into both epidermis and dermis
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High temperatures disrupt hydrogen bonds and hydrophobic interactions within protein structures, leading to misfolding, aggregation, and even endoplasmic reticulum stress, thereby initiating downstream cellular responses (Figure 1a) (Margulis et al., 2020)
In contrast, sAC induces cell proliferation through a PKA-independent, but EPAC/Rap1/B-Rafdependent, signaling pathway in prostate carcinoma cells (49)
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Crit Care Med , 2001
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