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This triple mechanism of action distinguishes retatrutide from existing approved therapies such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GIP/GLP-1 receptor agonist)

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It works by simultaneously activating the glucose-dependent insulinotropic polypeptide receptor (GIP-R) and glucagon-like peptide-1 receptor (GLP-1R), which results in increased insulin release, decreased glucagon secretion, reduced hunger, delayed gastric emptying, and significant weight loss

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