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The varying strategies of developing an ARKO line are important to note as characteristics such as the presence of the selection cassette, the promoter selected for transgene integration, the position of the loxP sites, or the utilized mouse background all likely contribute to differences in tissue selectivity, AR activity, and the resulting phenotypes [178, 201]
Some people are unable to manufacture Intrinsic Factor, a condition called pernicious anemia, making it impossible to absorb Vitamin B12 from foods or oral supplements
Therriault, A
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As levels decline with age, fatigue and cognitive decline can increase
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