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Human Medicines Division Pharmacovigilance Risk Assessment Committee (PRAC)
This creates a practical constraint: = exceeds 28-day window per reconstitution Solution: Only reconstitute the amount you'll use in 28 days
Dosing Convenience# Recommendation : MET-097i Reason : Once-monthly dosing with potential titration-free administration would reduce injection burden from 52 to 12 injections per year
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