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Its pharmacological activators, including oltipraz and bardoxolone methyl, have been shown to ameliorate cognitive deficits and attenuate lipid peroxidation damage in AD models ( 4.3 Immunomodulatory strategies for ferroptosis regulation in Alzheimers disease In Alzheimers disease (AD), ferroptosis is not only characterized by disrupted iron metabolism and lipid peroxidation, but also by the activation of immune cells including microglia, astrocytes, and T lymphocytes