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Intestinal GLP-1 and satiation: from man to rodents and back
A parallel line of work frames Alzheimers disease as a state of central insulin resistance, sometimes called type 3 diabetes, in which GLP-1R agonism restores neuronal insulin signalling, improves mitochondrial function, and reduces oxidative stress
Rhesus macaques were also used to study GLP-1s effects on pancreatic function and glucose metabolism, further validating the drugs mechanism and safety before human trials
Which of the GLP-1-based therapies can achieve the most desirable weight loss balanced with a manageable safety profile (e.g., GI events) and favorable dosing schedule
Does cyanocobalamin need to be refrigerated
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