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Tirzepide operates on GLP-1 receptors, similar to semaglutide, and also targets an additional receptor called GIP, making it a unique "twincretin" that has demonstrated superior weight loss and glucose control
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Metformin Metformin is a biguanide that improves glycemic control in patients with type 2 diabetes mellitus, lowering both basal and postprandial plasma glucose
While SSRIs have been associated with improved subjective sleep in clinically depressed patients, their effects on sleep in the general population are not well studied
These are dose-dependent and typically decrease over time
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