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In addition to the well-characterized catalytic activity, recent evidence has shown that certain GST isozymes can regulate mitogen-activated protein kinases or can facilitate the addition of glutathione to cysteine residues in target proteins ( S -glutathionylation)
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We demonstrated that TrkB signalling in these neurons is essential to maintain normal locomotor behaviour consistent with the initial hyperkinetic symptoms of HD and suggested that TrkB signalling deficiency may contribute effectively to HD motor symptoms 13
Reconstitution requires bacteriostatic water (water containing 0.9% benzyl alcohol as a preservative): Standard Reconstitution: Add 2 mL of bacteriostatic water to a 5 mg vial, creating a concentration of 2.5 mg/mL (2,500 mcg/mL)
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