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In spite of promising preclinical and clinical outcomes, the best dosing, treatment duration, and combinatorial strategies for antioxidant treatments in ASD are poorly characterized

FSP1 is required for the growth of multiple genetic subtypes of LUAD and pancreatic cancer To more thoroughly interrogate the functional importance of Fsp1 for tumorigenesis and the translational potential for targeting Fsp1 in cancer, we assessed the requirement of FSP1 for growth of xenograft tumors from human LUAD cell lines harboring a variety of driver mutations, including KRAS, NRAS, EGFR, TP53, STK11 and KEAP1