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Exenatide (twice-daily) and lixisenatide are GLP-1 receptor agonists based on exendin-4 that overcome cleavage by DPP-4, however, their half remains short with ~ 24 h due to renal elimination

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26 The two versions of GLP-1 are ~50% homologous with glucagon, 189 and they both have similar affinity for the GLP-1R and also exhibit similar potency