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Given the theoretical cancer concern (disrupting senescence surveillance) and absence of human pharmacokinetic data, caution is warranted

Notwithstanding the promise of ferroptosis in preclinical models, its clinical translation faces significant hurdles, particularly in drug delivery and on-target/off-tumor toxicity

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TB-500 is mainly associated with cell migration and actin dynamics, while GHK-Cu is recognised for its effects on extracellular matrix biology, collagen metabolism and regenerative signalling