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mibavademab, a leptin receptor agonist (NCT06373146)
Anna Garrett is a menopause expert and Doctor of Pharmacy
In the obesity trial, maximal WL was achieved with retatrutide 12 mg after 48 weeks: -24.2% vs
Side effects are real but manageable
Bisubstrate inhibitors such as NS1, LL320, and II399 based on adenosyl scaffolds have shown promise in this regard 199,200,201
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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