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Disruption of proteostasis is now recognized as a core pathological mechanism across cardiomyopathies, ischemic heart disease, arrhythmias, and heart failure, linking molecular protein quality control failure to tissue remodeling and clinical disease progression

Hyperglycemia may directly cause oxidative stress in all retinal cells or contribute to oxygen deficits in the inner retinal layers due to the retinas high metabolic activity, making it prone to oxidative stress

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Nitric oxide serves as a potent vasodilator that relaxes blood vessels, enhancing blood flow and oxygen delivery to muscle tissues