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If any of these changes appear, the solution should not be considered reliable for continued research use, regardless of how much time has technically elapsed since reconstitution
The longer it simmers, the more nutritious it becomes
Interestingly, a mouse model of schizophrenia induced by perinatal treatment with ketamine was reported to display a persistent reduction of glutathione and increased oxidative stress in the medial prefrontal cortex [87], which was accompanied by impaired mitochondrial function, reduced parvalbumin expression, and disruption of the excitationinhibition balance (reduced inhibition onto layer 2/3 pyramidal cells, and increased excitatory drive onto parvalbumin-positive interneurons)
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For consistency across studies, document solvent, concentration, storage temperature, freezethaw cycles, and light exposure conditions in experimental records
