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The anti-aging and skin rejuvenation research protocols from clinical literature use 1mg daily as a starting point, with 2mg daily for accelerated protocols or those specifically targeting tissue repair during active fat loss

JAMA 325(14):14141425 Garvey WT, Batterham RL, Bhatta M et al (2022) Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial