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Since melanin is responsible for skin color and dark spots, reducing its synthesis can promote a more even skin tone and diminish hyperpigmentation

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The SURMOUNT-5 trial, published in 2025 in the New England Journal of Medicine, compared tirzepatide directly against a GLP-1 comparator over 72 weeks

It tackles these inflammatory pathways and reverses that process so you have less inflammation even at the tissue level, Coviello explained

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