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The hormone GLP-1 is also a neurotransmitter and communicates directly with an area in the brain that regulates appetite, called the hypothalamus

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The long duration of follow-up and consistent effects across renal measures substantiate high-certainty evidence for renoprotection independent of glycemic control

These hepatic improvements, which may be associated with cotadutide's glucagon activity, indicate its potential as a therapeutic option for nonalcoholic steatohepatitis (NASH)