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For patients experiencing acid reflux or dyspepsia whilst taking Rybelsus, several alternative management strategies may be considered, particularly if omeprazole timing proves problematic or if PPI therapy is not optimally effective: Lifestyle and dietary modifications: Weight reduction (if appropriate) can significantly improve GORD symptoms and is complementary to Rybelsus therapy for diabetes Avoid large meals, particularly in the evening

PMID 35301358

Diarrhea The second most common side effect, affecting a higher percentage of participants at higher doses

the present application also relates to a recombinant process for the preparation of semapeptide